The emergence and spread of antimicrobial resistance:
a silent and devastating pandemic

The emergence and spread of bacteria associated withantimicrobial resistance (AMR)represent a major global public health and animal health issue. The World Health Organization estimates that, if the situation is not brought under control quickly, by 2050 AMR could become the leading cause of global mortality, surpassing certain chronic diseases such as cancer.
Antimicrobial resistance (AMR) is also an environmental issue, characterized by complex interactions involving various microbial populations and affecting human health, animal health, and the environment. Furthermore, thephenomenonof AMR is closely linked to broader issues such as climate change, health crises, and inequalities in access to healthcare.
It therefore makes sense to address the issue of resistance by taking this complexity into account, through a coordinated, multisectoral approach—as advocated by the“One Health”strategy—that integrates humans, animals, and the environment. This “One Health” approach, applied to the spread of AMR, makes all the more sense given that it is estimated that, over the past few decades, 75% of emerging or re-emerging infectious diseases in humans are of zoonotic origin.
Given the urgency of the situation, the main regional and interregional stakeholders involved in the fight against AMR and in the “One Health” approach—the IRD, the CNRS, Ifremer, CIRAD, the University of Montpellier, Paul-Valéry University of Montpellier, the University of Social Sciences and Humanities Lyon 3, GRET France, the Mérieux Foundation, and the Faculty of Medicine and the Montpellier University Hospital through the bacteriology team and the EPath research department (UMR-MIVEGEC) led by Prof. Sylvain Godreuil — have developed a call to action in support of the fight against AMR through a “One Health” approach, based on the drafting of aPolicy Brief.
The purpose of this document is to explain and demonstrate, based on data from the scientific literature, the urgency of the AMR issue and the need to address it through a “One Health” approach. Through concrete recommendations, our goal is to help decision-makers take informed action.
In the short term, it will be sent to the France–AMR Mirror Group and to public authorities involved in this issue, particularly in conjunction withWorld AMR Awareness Week (November 18–24, 2025). ThisPolicy Briefwill also be distributed to ASEAN ministers and members, as well as to other French participants in theOne Health Conferencescheduled for November 25 and November 26, 2025 in Jakarta.
Finally, on April 7, 2026, on World Health Day, France will host the“One Health”summit in Lyon. This advocacy message will be shared with all key stakeholders from the public and private sectors, academia, international organizations, international donors, local governments, and civil society, whose common objectives will be:
(i) to translate commitments into concrete actions;
(ii) to propose innovative solutions;
iii) and to build sustainable cooperation for the health of all: humans, animals, plants, and the planet.