The emergence and spread of antimicrobial resistance:
a silent and devastating pandemic

The emergence and spread of bacteria associated with antimicrobial resistance (AMR ) is a major global problem in terms of public and animal health. The World Health Organization estimates that, if the situation is not rapidly brought under control, by 2050 AMR could become the world's leading cause of death, ahead of chronic diseases such as cancer.
AMR is also an environmental problem, characterized by complex interactions involving various microbial populations and affecting human health, animal health and the environment. Furthermore, the AMR phenomenon is closely linked to more global issues such as climate change, health crises and inequalities in access to healthcare.
It therefore makes sense to address the phenomenon of resistance in a way that takes account of this complexity, based on a coordinated, multi-sectoral approach, as advocated by the "One Health" strategy - integrating humans, animals and the environment. This "One Health" approach, applied to the spread of AMR, makes all the more sense given that it is estimated that, over the last few decades, 75% of emerging or re-emerging infectious diseases in humans are of zoonotic origin.
Given the urgency of the situation, the main regional and inter-regional players involved in the fight against AMR and in the "One Health" approach - IRD, CNRS, Ifremer, CIRAD, the University of Montpellier, the Paul-Valéry University of Montpellier, the University of Social Sciences and Humanities Lyon 3, GRET France, Fondation Mérieux and the UFR de Médecine and CHU de Montpellier - through the bacteriology team and the EPath research department (UMR- MIVEGEC) headed by Pr Sylvain Godreuil - have drawn up a plea to combat AMR through a "One Health" approach, based on the drafting of a Policy Brief.
The aim of this document is to explain and convince, on the basis of scientific literature, the urgency of the AMR problem and the need to find solutions through a "One Health" approach. Through concrete recommendations, our aim is to help decision-makers take informed action.
In the short term, it will be sent to the France-AMR mirror group and to public authorities involved in this theme, in particular on the occasion of World AMR Awareness Week ( November 18 to 24, 2025). The Policy Brief will also be given to ASEAN ministers and members, as well as to other French participants in the One Health Conference scheduled for November 25 and November 26, 2025 in Jakarta.
Finally, on April 7, 2026on World Health Day, France will host the "One Health" summit in Lyon. This plea will be conveyed to all key players in the public and private sectors, academia, international organizations, international donors, local authorities and civil society, with the common objectives of :
i) turn commitments into concrete actions;
ii) propose innovative solutions;
iii) and to build sustainable cooperation for the health of all: humans, animals, plants and the planet.